| First Author | Utz B | Year | 2020 |
| Journal | Sci Rep | Volume | 10 |
| Issue | 1 | Pages | 18733 |
| PubMed ID | 33127915 | Mgi Jnum | J:298924 |
| Mgi Id | MGI:6472214 | Doi | 10.1038/s41598-020-75411-z |
| Citation | Utz B, et al. (2020) Assessment of the WAP-Myc mouse mammary tumor model for spontaneous metastasis. Sci Rep 10(1):18733 |
| abstractText | Breast cancer is the most common form of cancer in women. Despite significant therapeutic advances in recent years, breast cancer also still causes the greatest number of cancer-related deaths in women, the vast majority of which (> 90%) are caused by metastases. However, very few mouse mammary cancer models exist that faithfully recapitulate the multistep metastatic process in human patients. Here we assessed the suitability of a syngrafting protocol for a Myc-driven mammary tumor model (WAP-Myc) to study autochthonous metastasis. A moderate but robust spontaneous lung metastasis rate of around 25% was attained. In addition, increased T cell infiltration was observed in metastatic tumors compared to donor and syngrafted primary tumors. Thus, the WAP-Myc syngrafting protocol is a suitable tool to study the mechanisms of metastasis in MYC-driven breast cancer. |
