| Primary Identifier | MGI:3054417 | Allele Type | Transgenic |
| Attribute String | Humanized sequence, Inserted expressed sequence | Gene | Tg(DM15)26Bew |
| Strain of Origin | FVB | Is Recombinase | false |
| Is Wild Type | false |
| description | Younger mice do not exhibit typical symptoms of Dystrophia Myotonica 1 (J:33711), however older mice (11-15 months of age) develop the distinctive traits of Dystrophia Myotonica 1 (J:93614). |
| molecularNote | This transgene contains a 14 kb genomic fragment including all of the human DM15 gene and the last exon from the upstream gene DMWD. Two founder lines were generated Tg26 and Tg15 with 25 and 20 copies of the transgene integrated, respectively. Expression is seen in the muscle and smooth muscle containing tissues. Tg26 has a higher level of expression and more severe phenotype compared to Tg15 which has lower expression and a milder version of the same phenotype seen in Tg26. |
