| Primary Identifier | MGI:3054664 | Allele Type | Transgenic |
| Attribute String | Inserted expressed sequence | Gene | Tg(H2-K-Fos)1Wag |
| Strain of Origin | (C57BL/6 x SJL)F2 | Is Recombinase | false |
| Is Wild Type | false |
| description | 5 independent transgenic lines were generated from founders designated 247-1, 248-6, 248-7 and 263-3; two lines were derived from a single founder, 247-1, that had integrated the Tg in two sites. Little distinction is made among them in the original reference. |
| molecularNote | The transgene comprises a 4.1 kb genomic DNA fragment including the translation initiation codon, all exons and introns, and the polyadenylation signal of the mouse FBJ osteosarcoma [proto-] oncogene joined to a 2 kb fragment containing the promoter and the first nine transcribed base pairs of the mouse H2-Kb gene. All five transgenic lines expressed transgenic mRNA in spleen, thymus, lung and salivary gland, most at high levels; 4/5, at low to moderate levels, in liver and muscle; 3/5 at low levels in heart, gonads and kidney; one, at a low level, in pancreas; and none in brain or bone marrow. |
