| Primary Identifier | MGI:3055339 | Allele Type | Transgenic |
| Attribute String | Inserted expressed sequence | Gene | Tg(TCRB)C14Jg |
| Strain of Origin | C57BL/6 x DBA/2 | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | A functionally rearranged Tcrb gene was used in the construction of this transgene A recombined Tcrb gene with Vbeta8.2/Dbeta2/Jbeta2.6 gene segments was cloned from the B10.PL hybridoma "172.10". This hybridoma was specific for the 11 amino-terminal residues of myelin basic protein (MBP). Crossing this line with the Tg(TCRA)B1Jg line produces a T cell with a transgenic TCR that has affinity for the first 11 amino acids of MBP. In these doubly transgenic mice, almost all of the CD3+ cells express the transgenic Tcrb gene. |
