| Primary Identifier | MGI:3055355 | Allele Type | Transgenic |
| Attribute String | Humanized sequence, Inserted expressed sequence | Gene | Tg(CD8aCD8b)57Scr |
| Strain of Origin | C57BL/6 | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | The transgene contains the human CD8 alpha and beta chain genes driven by the T cell-specific Lck promoter. CD8alpha-alpha homodimers were expressed on 62% of thymocytes and CD8alpha-beta heterodimers on 14% of thymocytes. Peripheral T cells preferentially expressed the CD8alpha-beta heterodimers at a 4:1 ratio. Human CD8alpha was detected on both CD4+ and CD8+ T cells. |
