|  Help  |  About  |  Contact Us

Publication : Cxxc finger protein 1 maintains homeostasis and function of intestinal group 3 innate lymphoid cells with aging.

First Author  Shen X Year  2023
Journal  Nat Aging Volume  3
Issue  8 Pages  965-981
PubMed ID  37429951 Mgi Jnum  J:356820
Mgi Id  MGI:7762912 Doi  10.1038/s43587-023-00453-7
Citation  Shen X, et al. (2023) Cxxc finger protein 1 maintains homeostasis and function of intestinal group 3 innate lymphoid cells with aging. Nat Aging 3(8):965-981
abstractText  Aging is accompanied by homeostatic and functional dysregulation of multiple immune cell subsets. Group 3 innate lymphoid cells (ILC3s) constitute a heterogeneous cell population that plays pivotal roles in intestinal immunity. In this study, we found that ILC3s in aged mice exhibited dysregulated homeostasis and function, leading to bacterial and fungal infection susceptibility. Moreover, our data revealed that the enrichment of the H3K4me3 modification in effector genes of aged gut CCR6(+) ILC3s was specifically decreased compared to young mice counterparts. Disruption of Cxxc finger protein 1 (Cxxc1) activity, a key subunit of H3K4 methyltransferase, in ILC3s led to similar aging-related phenotypes. An integrated analysis revealed Kruppel-like factor 4 (Klf4) as a potential Cxxc1 target. Klf4 overexpression partially restored the differentiation and functional defects seen in both aged and Cxxc1-deficient intestinal CCR6(+) ILC3s. Therefore, these data suggest that targeting intestinal ILC3s may provide strategies to protect against age-related infections.
Quick Links:
 
Quick Links:
 

Expression

Publication --> Expression annotations

 

Other

13 Bio Entities

Trail: Publication

0 Expression