| First Author | Nava P | Year | 2011 |
| Journal | EMBO Rep | Volume | 12 |
| Issue | 4 | Pages | 314-20 |
| PubMed ID | 21372850 | Mgi Jnum | J:171060 |
| Mgi Id | MGI:4948388 | Doi | 10.1038/embor.2011.16 |
| Citation | Nava P, et al. (2011) JAM-A regulates epithelial proliferation through Akt/beta-catenin signalling. EMBO Rep 12(4):314-20 |
| abstractText | Expression of the tight junction protein junctional adhesion molecule-A (JAM-A) has been linked to proliferation and tumour progression. However, a direct role for JAM-A in regulating proliferative processes has not been shown. By using complementary in vivo and in vitro approaches, we demonstrate that JAM-A restricts intestinal epithelial cell (IEC) proliferation in a dimerization-dependent manner, by inhibiting Akt-dependent beta-catenin activation. Furthermore, IECs from transgenic JAM-A(-/-)/beta-catenin/T-cell factor reporter mice showed enhanced beta-catenin-dependent transcription. Finally, inhibition of Akt reversed colonic crypt hyperproliferation in JAM-A-deficient mice. These data establish a new link between JAM-A and IEC homeostasis. |
