| First Author | Aoi W | Year | 2023 |
| Journal | iScience | Volume | 26 |
| Issue | 3 | Pages | 106251 |
| PubMed ID | 36915683 | Mgi Jnum | J:339212 |
| Mgi Id | MGI:7446041 | Doi | 10.1016/j.isci.2023.106251 |
| Citation | Aoi W, et al. (2023) Exercise-acclimated microbiota improves skeletal muscle metabolism via circulating bile acid deconjugation. iScience 26(3):106251 |
| abstractText | Habitual exercise alters the intestinal microbiota composition, which may mediate its systemic benefits. We examined whether transplanting fecal microbiota from trained mice improved skeletal muscle metabolism in high-fat diet (HFD)-fed mice. Fecal samples from sedentary and exercise-trained mice were gavage-fed to germ-free mice. After receiving fecal samples from trained donor mice for 1 week, recipient mice had elevated levels of AMP-activated protein kinase (AMPK) and insulin growth factor-1 in skeletal muscle. In plasma, bile acid (BA) deconjugation was found to be promoted in recipients transplanted with feces from trained donor mice; free-form BAs also induced more AMPK signaling and glucose uptake than tauro-conjugated BAs. The transplantation of exercise-acclimated fecal microbiota improved glucose tolerance after 8 weeks of HFD administration. Intestinal microbiota may mediate exercise-induced metabolic improvements in mice by modifying circulating BAs. Our findings provide insights into the prevention and treatment of metabolic diseases. |
