| First Author | Hodge CW | Year | 2008 |
| Journal | Genes Brain Behav | Volume | 7 |
| Issue | 1 | Pages | 96-102 |
| PubMed ID | 17559417 | Mgi Jnum | J:145604 |
| Mgi Id | MGI:3835276 | Doi | 10.1111/j.1601-183X.2007.00332.x |
| Citation | Hodge CW, et al. (2008) Deletion of the 5-HT(3A)-receptor subunit blunts the induction of cocaine sensitization. Genes Brain Behav 7(1):96-102 |
| abstractText | Serotonin (5-HT) receptors are classified into seven groups (5-HT(1-7)), comprising at least 14 structurally and pharmacologically distinct receptor subtypes. Pharmacological antagonism of ionotropic 5-HT(3) receptors has been shown to modulate both behavioral and neurochemical aspects of the induction of sensitization to cocaine. It is not known, however, if specific molecular subunits of the 5-HT(3) receptor influence the development of cocaine sensitization. To address this question, we studied the effects of acute and chronic intermittent cocaine administration in mice with a targeted deletion of the gene for the 5-HT(3A)-receptor subunit (5-HT(3A)-/-). 5-HT(3A) (-/-) mice showed blunted induction of cocaine-induced locomotor sensitization as compared with wild-type littermate controls. 5-HT(3A) (-/-) mice did not differ from wild-type littermate controls on measures of basal motor activity or response to acute cocaine treatment. Enhanced locomotor response to saline injection following cocaine sensitization was observed equally in 5-HT(3A) (-/-) and wild-type mice suggesting similar conditioned effects associated with chronic cocaine treatment. These data show a role for the 5-HT(3A)-receptor subunit in the induction of behavioral sensitization to cocaine and suggest that the 5-HT(3A) molecular subunit modulates neurobehavioral adaptations to cocaine, which may underlie aspects of addiction. |
