| First Author | Murthy S | Year | 2014 |
| Journal | Nat Commun | Volume | 5 |
| Pages | 5524 | PubMed ID | 25409778 |
| Mgi Jnum | J:250022 | Mgi Id | MGI:6100410 |
| Doi | 10.1038/ncomms6524 | Citation | Murthy S, et al. (2014) Serotonin receptor 3A controls interneuron migration into the neocortex. Nat Commun 5:5524 |
| abstractText | Neuronal excitability has been shown to control the migration and cortical integration of reelin-expressing cortical interneurons (INs) arising from the caudal ganglionic eminence (CGE), supporting the possibility that neurotransmitters could regulate this process. Here we show that the ionotropic serotonin receptor 3A (5-HT(3A)R) is specifically expressed in CGE-derived migrating interneurons and upregulated while they invade the developing cortex. Functional investigations using calcium imaging, electrophysiological recordings and migration assays indicate that CGE-derived INs increase their response to 5-HT(3A)R activation during the late phase of cortical plate invasion. Using genetic loss-of-function approaches and in vivo grafts, we further demonstrate that the 5-HT(3A)R is cell autonomously required for the migration and proper positioning of reelin-expressing CGE-derived INs in the neocortex. Our findings reveal a requirement for a serotonin receptor in controlling the migration and laminar positioning of a specific subtype of cortical IN. |
