| Primary Identifier | MGI:3057129 | Allele Type | Transgenic |
| Attribute String | Humanized sequence, Inserted expressed sequence | Gene | Tg(MAPT)8cPdav |
| Strain of Origin | Swiss Webster x (C57BL/6 x DBA)F1 | Is Recombinase | false |
| Is Wild Type | false |
| description | Mice that are homozygous for the Mapttm1(GFP)Klt allele and hemizygous for the transgene are viable and fertile. Although no endogenous mouse MAPT is detected, all six isoforms (including both 3R and 4R forms) of human MAPT are expressed. Hyperphosphorylated MAPT is detected in cell bodies and dendrites by 3 months of age. Paired helical filaments of aggregated insoluble MAPT can be isolated from brain tissue as early as 2 months of age. |
| molecularNote | The transgene contains the coding sequence, intronic regions, and regulatory elements of the human microtubule-associated protein tau (MAPT) gene. Tg(MAPT)8cPdav integrated on chromosome 7 [104,477,768-104,477,769 ; mm10] in an intron of the tripartite motif-containing 30D locus (Trim30d). The transgene copy number was not calculated. It was not determined if this resulted in any genomic duplication(s) or if this alters endogenous Trim30d expression. |
