| Primary Identifier | MGI:3057167 | Allele Type | Transgenic |
| Attribute String | Humanized sequence, Inserted expressed sequence | Gene | Tg(Prnp-SNCA*A53T)83Vle |
| Strain of Origin | C57BL/6 x C3H | Is Recombinase | false |
| Is Wild Type | false |
| description | This line was originally designated M83. Line M91 was also generated. |
| molecularNote | The transgene contains the mouse prion protein promoter, its 5' and 3' untranslated regions, and a human alpha synuclein cDNA sequence encoding a mutated protein with an Ala53Thr mutation. Transgene expression was detected in the cerebral cortex, spinal cord, and cerebellum. Transgene insertion occurred on Chr 12. |
