| First Author | Ma X | Year | 2021 |
| Journal | Biomolecules | Volume | 11 |
| Issue | 9 | PubMed ID | 34572500 |
| Mgi Jnum | J:339102 | Mgi Id | MGI:6764745 |
| Doi | 10.3390/biom11091287 | Citation | Ma X, et al. (2021) Blood-Derived alpha-Synuclein Aggregated in the Substantia Nigra of Parabiotic Mice. Biomolecules 11(9) |
| abstractText | As a pathological biomarker of Parkinson's disease, alpha-synuclein is thought to be a prion-like protein, but evidence for the transmission of alpha-synuclein from blood to the brain is unclear. The goals of this study were to determine whether blood-derived alpha-synuclein could enter the brains of mice and whether alpha-synuclein in the brain could be cleared by parabiosis. Heterochronic parabiosis was performed on SNCA(A53T) transgenic mice (A53T mice) and wildtype mice. The levels of human alpha-synuclein in the blood and substantia nigra of wildtype mice were significantly increased after 4-month parabiosis with A53T mice. Moreover, the expression of alpha-synuclein filament, but not of total alpha-synuclein, was significantly increased in the substantia nigra of wildtype mice that were paired with A53T mice. However, the levels of human alpha-synuclein displayed no significant change in the serum, blood, or substantia nigra of A53T mice. These results provide direct evidence that pathological alpha-synuclein can be transmitted from blood to the brain in the heterochronic parabiosis system; however, it appears to be difficult to clear it from the brain in a short period of time. |
