| First Author | Ha TY | Year | 2021 |
| Journal | Mol Brain | Volume | 14 |
| Issue | 1 | Pages | 122 |
| PubMed ID | 34321069 | Mgi Jnum | J:328429 |
| Mgi Id | MGI:6762294 | Doi | 10.1186/s13041-021-00834-2 |
| Citation | Ha TY, et al. (2021) Age-related increase in caveolin-1 expression facilitates cell-to-cell transmission of alpha-synuclein in neurons. Mol Brain 14(1):122 |
| abstractText | Parkinson's disease (PD) is the second most prevalent neurodegenerative disease, with aging being considered the greatest risk factor for developing PD. Caveolin-1 (Cav-1) is known to participate in the aging process. Recent evidence indicates that prion-like propagation of misfolded alpha-synuclein (alpha-syn) released from neurons to neighboring neurons plays an important role in PD progression. In the present study, we demonstrated that cav-1 expression in the brain increased with age, and considerably increased in the brain of A53T alpha-syn transgenic mice. Cav-1 overexpression facilitated the uptake of alpha-syn into neurons and formation of additional Lewy body-like inclusion bodies, phosphorylation of cav-1 at tyrosine 14 was found to be crucial for this process. This study demonstrates the relationship between age and alpha-syn spread and will facilitate our understanding of the molecular mechanism of the cell-to-cell transmission of alpha-syn. |
