| Primary Identifier | MGI:3057182 | Allele Type | Transgenic |
| Attribute String | Humanized sequence, Inserted expressed sequence | Gene | Cdh18 |
| Strain of Origin | C57BL/6 or CBA | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | The transgene contains sequence encoding human apolipoprotein E4 isoform under the control of the human glial fibrillary acidic protein (GFAP) promoter. Five lines were created (lines 1, 3, 11, 19 and 22) with line 1 being chosen as the representative line based on submission to the Jax repository. The pattern of expression of the human apolipoprotein E3 isoform (APOE3) transgenic product in these mice follows the endogenous mouse APOE and GFAP expression patterns in the brain. Human APOE3 is immunodetectable in glia and neuropil in developing and adult mutant mice. Line 1 inserted into coordinates 23364633-23373281 (Build GRCm38/mm10) resulting in an 8648 bp deletion. Founder line 1 has a copy number of 10-15. |
