| First Author | Delgado AC | Year | 2021 |
| Journal | Science | Volume | 372 |
| Issue | 6547 | Pages | 1205-1209 |
| PubMed ID | 34112692 | Mgi Jnum | J:311451 |
| Mgi Id | MGI:6716120 | Doi | 10.1126/science.abg8467 |
| Citation | Delgado AC, et al. (2021) Release of stem cells from quiescence reveals gliogenic domains in the adult mouse brain. Science 372(6547):1205-1209 |
| abstractText | Quiescent neural stem cells (NSCs) in the adult mouse ventricular-subventricular zone (V-SVZ) undergo activation to generate neurons and some glia. Here we show that platelet-derived growth factor receptor beta (PDGFRbeta) is expressed by adult V-SVZ NSCs that generate olfactory bulb interneurons and glia. Selective deletion of PDGFRbeta in adult V-SVZ NSCs leads to their release from quiescence, uncovering gliogenic domains for different glial cell types. These domains are also recruited upon injury. We identify an intraventricular oligodendrocyte progenitor derived from NSCs inside the brain ventricles that contacts supraependymal axons. Together, our findings reveal that the adult V-SVZ contains spatial domains for gliogenesis, in addition to those for neurogenesis. These gliogenic NSC domains tend to be quiescent under homeostasis and may contribute to brain plasticity. |
