| First Author | Kawano T | Year | 1997 |
| Journal | Science | Volume | 278 |
| Issue | 5343 | Pages | 1626-9 |
| PubMed ID | 9374463 | Mgi Jnum | J:323368 |
| Mgi Id | MGI:6872361 | Doi | 10.1126/science.278.5343.1626 |
| Citation | Kawano T, et al. (1997) CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramides. Science 278(5343):1626-9 |
| abstractText | Natural killer T (NKT) lymphocytes express an invariant T cell antigen receptor (TCR) encoded by the Valpha14 and Jalpha281 gene segments. A glycosylceramide-containing alpha-anomeric sugar with a longer fatty acyl chain (C26) and sphingosine base (C18) was identified as a ligand for this TCR. Glycosylceramide-mediated proliferative responses of Valpha14 NKT cells were abrogated by treatment with chloroquine-concanamycin A or by monoclonal antibodies against CD1d/Vbeta8, CD40/CD40L, or B7/CTLA-4/CD28, but not by interference with the function of a transporter-associated protein. Thus, this lymphocyte shares distinct recognition systems with either T or NK cells. |
