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Allele : Tg(LCK-NFKBIA)5Dwb transgene insertion 5, Dean W Ballard
Primary Identifier  MGI:3056807 Allele Type  Transgenic
Attribute String  Dominant negative, Humanized sequence, Inserted expressed sequence Gene  Tg(LCK-NFKBIA)5Dwb
Strain of Origin  C57BL/6 x DBA/2 Is Recombinase  false
Is Wild Type  false
molecularNote  An amino acid-truncated human NFKBIA gene (coding for amino acids 37-317) fused to a FLAG epitope was placed under the control of a human LCK promoter. The protein encoded by this transgene lacks sequences required for signal-dependent degradation and functions as a constitutive repressor of multiple NK-kappaB pathways. Transgene expression was readily detected in the thymus and spleen as determined by immunoblot analysis.
  • mutations:
  • Insertion
  • synonyms:
  • IkappaBalpha(deltaN),
  • IkappaNalphadeltaN-Tg,
  • IkappaBalpha(deltaN),
  • LCK,
  • LCK,
  • IkappaNalphadeltaN-Tg
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1 Feature

Trail: Allele

Genome

1 Expresses

Trail: Allele

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

2 Carried By

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0 Driven By

20 Publication categories

Trail: Allele




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