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Allele : Ret<tm3.1(RET)Jmi> ret proto-oncogene; targeted mutation 3.1, Jeffrey Milbrandt

Primary Identifier  MGI:3057333 Allele Type  Targeted
Attribute String  Dominant negative Gene  Ret
Transmission  Germline Strain of Origin  Not Specified
Is Recombinase  false Is Wild Type  false
molecularNote  Human RET9 cDNA with Y1062F and L985P mutations and a floxed neo were inserted into exon 1 of the endogenous locus. Leucine 985 was at the end of the kinase domain. Mating with mice expressing Cre in the germline excised the neo. RT-PCR showed expression of the mutant allele in brain.
  • mutations:
  • Insertion
  • synonyms:
  • RetDN,
  • RetDN,
  • Ret<DN>,
  • Ret<DN>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

6 Publication categories

Trail: Allele