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Allele : Ido1<tm1Alm> indoleamine 2,3-dioxygenase 1; targeted mutation 1, Andrew L Mellor

Primary Identifier  MGI:3505776 Allele Type  Targeted
Attribute String  Null/knockout Gene  Ido1
Transmission  Germline Strain of Origin  129X1/SvJ
Is Recombinase  false Is Wild Type  false
molecularNote  A Betagal and neomycin cassette replaced exons 3-5, which encode critical portions of the enzyme catalytic site. Also, a translation stop codon was introduced into exon 2. RT-PCR of total epididymis RNA from mutants showed no transcript was present. Western blot of mutant epididymis confirmed a lack of protein.
  • mutations:
  • Insertion,
  • Intragenic deletion
  • synonyms:
  • IDO<->,
  • IDO<->,
  • Ido1-KO,
  • Ido1<->,
  • Ido1<->,
  • Ido1-KO
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

2 Carried By

Trail: Allele

0 Driven By

143 Publication categories

Trail: Allele