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Allele : Th<tm2Te> tyrosine hydroxylase; targeted mutation 2, Ted Ebendal
Primary Identifier  MGI:3487230 Allele Type  Targeted
Attribute String  Hypomorph, Inserted expressed sequence Gene  Th
Inheritance Mode  Recessive Transmission  Germline
Strain of Origin  129X1/SvJ Is Recombinase  false
Is Wild Type  false
molecularNote  A DNA segment encoding a truncated version of bone morphogenic protein receptor, type II (serine/threonine kinase), preceded by an internal ribosome entry site (IRES) and followed by a frt-flanked neomycin resistance cassette, was introduced into the 3' untranslated region of the endogenous tyrosine hydroxylase gene. In situ hybridization and immunohistochemcal analysis revealed reduction in the levels of tyrosine hydroxylase mRNA and protein in brains of homozygous mice.
  • mutations:
  • Insertion
  • synonyms:
  • TEb-1,
  • B2+(Th-IRES-BMPR2trunc-neo+),
  • TEb-1,
  • B2+(Th-IRES-BMPR2trunc-neo+)
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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Trail: Allele




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