| First Author | Poncelet M | Year | 2003 |
| Journal | Neurosci Lett | Volume | 343 |
| Issue | 3 | Pages | 216-8 |
| PubMed ID | 12770700 | Mgi Jnum | J:108021 |
| Mgi Id | MGI:3622862 | Doi | 10.1016/s0304-3940(03)00397-5 |
| Citation | Poncelet M, et al. (2003) Overeating, alcohol and sucrose consumption decrease in CB1 receptor deleted mice. Neurosci Lett 343(3):216-8 |
| abstractText | Administration of the cannabinoid CB1 receptor antagonist SR141716 (3-10 mg/kg i.p.) abolished neuropeptide Y-induced overeating and significantly reduced ethanol and sucrose intake in CB1 wild-type (+/+) mice. In CB1 receptor knockout (-/-) mice, neuropeptide Y totally lost its capacity to increase food consumption. Similarly, sucrose and ethanol intakes were significantly lower in CB1-/- vs. CB1+/+ mice. In CB1 deficient mice, SR141716 had no effect in these models. |
