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Allele : Met<tm1Kln> met proto-oncogene; targeted mutation 1, Rudiger Klein
Primary Identifier  MGI:3510618 Allele Type  Targeted
Attribute String  Humanized sequence Gene  Met
Transmission  Germline Strain of Origin  Not Specified
Is Recombinase  false Is Wild Type  false
molecularNote  A mutant human cDNA coding for the transmembrane and cytoplasmic domains of the receptor was inserted in-frame into mouse genomic sequences. The mutations resulted in alterations of two multifunctional tyrosinase motifs: Y1349VHVNATY1356VNV to Y1349MDMSATY1356MDMS. A floxed neo included in the construct was excised by crossing with Cre deleter mice.
  • mutations:
  • Nucleotide substitutions
  • synonyms:
  • Met<2P>,
  • Met<2P>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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Trail: Allele




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