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Allele : Aqp2<tm1Ask> aquaporin 2; targeted mutation 1, A S Verkman

Primary Identifier  MGI:3511443 Allele Type  Targeted
Gene  Aqp2 Transmission  Germline
Strain of Origin  C57BL/6J x (Rb(11.16)2H x Rb(16.17)32Lub)F1 Is Recombinase  false
Is Wild Type  false
molecularNote  T126M, H122S, N124S and A125T mutations were introduced into exon 2 by homologous recombination. A Pol2neobpA cassette flanked by loxP sites was inserted into intron 2. Northern blot showed 3.5-fold marked-up regulation of the transcript in mutants.
  • mutations:
  • Nucleotide substitutions
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

5 Publication categories

Trail: Allele