Primary Identifier | MGI:3511443 | Allele Type | Targeted |
Gene | Aqp2 | Transmission | Germline |
Strain of Origin | C57BL/6J x (Rb(11.16)2H x Rb(16.17)32Lub)F1 | Is Recombinase | false |
Is Wild Type | false |
molecularNote | T126M, H122S, N124S and A125T mutations were introduced into exon 2 by homologous recombination. A Pol2neobpA cassette flanked by loxP sites was inserted into intron 2. Northern blot showed 3.5-fold marked-up regulation of the transcript in mutants. |