| First Author | Siarey RJ | Year | 1997 |
| Journal | Neurosci Lett | Volume | 232 |
| Issue | 3 | Pages | 131-4 |
| PubMed ID | 9310297 | Mgi Jnum | J:174280 |
| Mgi Id | MGI:5056183 | Doi | 10.1016/s0304-3940(97)00581-8 |
| Citation | Siarey RJ, et al. (1997) Responses to NMDA in cultured hippocampal neurons from trisomy 16 embryonic mice. Neurosci Lett 232(3):131-4 |
| abstractText | The trisomy 16 (Ts16) mouse is regarded as a model of human trisomy 21 (Ts21), or Down syndrome. The ionic current evoked by the glutamate receptor agonist N-methyl-D-aspartate (NMDA) was investigated in cultured hippocampal neurons from embryonic Ts16 and control diploid mice. In both Ts16 and control neurons, NMDA- (6-150 microM) evoked a similar inward current. The reversal potential, the minimum current, the dose response plot of the conductance, the effect of Mg2+ on the current-voltage plot and the inhibition by D-2-amino-5-phosphonovaleric acid (AP5; 50 microM) showed no significant difference between Ts16 and control neurons. These data suggest that, although voltage-dependent ion channels are reported to have altered active properties in Ts16 neurons, NMDA-evoked currents are not altered. |
