| First Author | Demas GE | Year | 1998 |
| Journal | Behav Brain Res | Volume | 90 |
| Issue | 2 | Pages | 199-201 |
| PubMed ID | 9521551 | Mgi Jnum | J:95722 |
| Mgi Id | MGI:3526845 | Doi | 10.1016/s0166-4328(97)00116-2 |
| Citation | Demas GE, et al. (1998) Impaired spatial working and reference memory in segmental trisomy (Ts65Dn) mice. Behav Brain Res 90(2):199-201 |
| abstractText | To evaluate the cognitive phenotype of the segmental trisomy 16 (Ts65Dn) mouse, a model of Down Syndrome (DS, trisomy 21), we assessed spatial working and reference memory using a 12-arm radial maze (RAM). Ts65Dn mice made a greater number of reference memory errors across trials compared to control mice. Both genotypes showed improvement across trials, although improvement was slower in Ts65Dn mice. Ts65Dn mice also made a greater number of working memory errors on the RAM, and in contrast to control mice, did not improve across trials, always performing at near-chance levels. These results provide evidence for both spatial working and reference memory deficits in Ts65Dn mice, characteristics of cognitive dysfunction. |
