| First Author | Summermatter S | Year | 2013 |
| Journal | Proc Natl Acad Sci U S A | Volume | 110 |
| Issue | 21 | Pages | 8738-43 |
| PubMed ID | 23650363 | Mgi Jnum | J:197316 |
| Mgi Id | MGI:5492172 | Doi | 10.1073/pnas.1212976110 |
| Citation | Summermatter S, et al. (2013) Skeletal muscle PGC-1alpha controls whole-body lactate homeostasis through estrogen-related receptor alpha-dependent activation of LDH B and repression of LDH A. Proc Natl Acad Sci U S A 110(21):8738-43 |
| abstractText | The peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha) controls metabolic adaptations. We now show that PGC-1alpha in skeletal muscle drives the expression of lactate dehydrogenase (LDH) B in an estrogen-related receptor-alpha-dependent manner. Concomitantly, PGC-1alpha reduces the expression of LDH A and one of its regulators, the transcription factor myelocytomatosis oncogene. PGC-1alpha thereby coordinately alters the composition of the LDH complex and prevents the increase in blood lactate during exercise. Our results show how PGC-1alpha actively coordinates lactate homeostasis and provide a unique molecular explanation for PGC-1alpha-mediated muscle adaptations to training that ultimately enhance exercise performance and improve metabolic health. |
