| First Author | Baker K | Year | 2013 |
| Journal | Immunity | Volume | 39 |
| Issue | 6 | Pages | 1095-107 |
| PubMed ID | 24290911 | Mgi Jnum | J:209206 |
| Mgi Id | MGI:5566709 | Doi | 10.1016/j.immuni.2013.11.003 |
| Citation | Baker K, et al. (2013) Neonatal Fc receptor expression in dendritic cells mediates protective immunity against colorectal cancer. Immunity 39(6):1095-107 |
| abstractText | Cancers arising in mucosal tissues account for a disproportionately large fraction of malignancies. Immunoglobulin G (IgG) and the neonatal Fc receptor for IgG (FcRn) have an important function in the mucosal immune system that we have now shown extends to the induction of CD8(+) T cell-mediated antitumor immunity. We demonstrate that FcRn within dendritic cells (DCs) was critical for homeostatic activation of mucosal CD8(+) T cells that drove protection against the development of colorectal cancers and lung metastases. FcRn-mediated tumor protection was driven by DCs activation of endogenous tumor-reactive CD8(+) T cells via the cross-presentation of IgG complexed antigens (IgG IC), as well as the induction of cytotoxicity-promoting cytokine secretion, particularly interleukin-12, both of which were independently triggered by the FcRn-IgG IC interaction in murine and human DCs. FcRn thus has a primary role within mucosal tissues in activating local immune responses that are critical for priming efficient anti-tumor immunosurveillance. |
