| First Author | Everett CA | Year | 2004 |
| Journal | Reproduction | Volume | 128 |
| Issue | 5 | Pages | 565-71 |
| PubMed ID | 15509702 | Mgi Jnum | J:93219 |
| Mgi Id | MGI:3056246 | Doi | 10.1530/rep.00325 |
| Citation | Everett CA, et al. (2004) Genetic influences on ovulation of primary oocytes in LT/Sv strain mice. Reproduction 128(5):565-571 |
| abstractText | A high proportion of LT/Sv strain oocytes arrest in meiotic metaphase I (MI) and are ovulated as diploid primary oocytes rather than haploid secondary oocytes. (Mus musculus castaneus x LT/SvKau)F1 x LT/SvKau backcross females were analysed for the proportion of oocytes that arrested in MI and typed by PCR for a panel of microsatellite DNA sequences (simple sequence repeat polymorphisms) that differed between strain LT/SvKau and M. m. castaneus. This provided a whole genome scan of 86 genetic markers distributed over all 19 autosomes and the X chromosome, and revealed genetic linkage of the MI arrest phenotype to markers on chromosomes 1 and 9. Identification of these two chromosomal regions should facilitate the identification of genes involved in mammalian oocyte maturation and the control of meiosis. |
