| First Author | Kim JG | Year | 2014 |
| Journal | Nat Neurosci | Volume | 17 |
| Issue | 7 | Pages | 908-10 |
| PubMed ID | 24880214 | Mgi Jnum | J:213808 |
| Mgi Id | MGI:5586620 | Doi | 10.1038/nn.3725 |
| Citation | Kim JG, et al. (2014) Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding. Nat Neurosci 17(7):908-10 |
| abstractText | We found that leptin receptors were expressed in hypothalamic astrocytes and that their conditional deletion led to altered glial morphology and synaptic inputs onto hypothalamic neurons involved in feeding control. Leptin-regulated feeding was diminished, whereas feeding after fasting or ghrelin administration was elevated in mice with astrocyte-specific leptin receptor deficiency. These data reveal an active role of glial cells in hypothalamic synaptic remodeling and control of feeding by leptin. |
