| Primary Identifier | MGI:3513253 | Allele Type | Targeted |
| Attribute String | Inserted expressed sequence | Gene | Brca1 |
| Transmission | Germline | Strain of Origin | 129S6/SvEvTac |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A serine to alanine substitution at amino acid 971 (S971A) was introduced into exon 11 and a floxed neo cassette upstream of exon 11 via homologous recombination. Mating with mice expressing cre recombinase in the germ line excised the floxed neo. This allele results in a mutation of the Chek2 phosphorylation site. RT-PCR showed that transcript is expressed at a level comparable to wild-type. |
