Primary Identifier | MGI:3521860 | Allele Type | Targeted |
Attribute String | Inserted expressed sequence, Null/knockout | Gene | Erbb2 |
Transmission | Germline | Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> |
Is Recombinase | false | Is Wild Type | false |
molecularNote | A targeting vector was designed to replace the first coding exon with the rat Erbb2 cDNA with the Y1227F mutation, resulting in the loss of the direct binding site for Shc1. A neo was also inserted. Analysis of the RT-PCR product indicated that mutants only expressed the rat cDNA. |