| First Author | Sato Y | Year | 2011 |
| Journal | Science | Volume | 333 |
| Issue | 6043 | Pages | 769-73 |
| PubMed ID | 21817055 | Mgi Jnum | J:174418 |
| Mgi Id | MGI:5086019 | Doi | 10.1126/science.1204144 |
| Citation | Sato Y, et al. (2011) Cartilage acidic protein-1B (LOTUS), an endogenous Nogo receptor antagonist for axon tract formation. Science 333(6043):769-73 |
| abstractText | Neural circuitry formation depends on the molecular control of axonal projection during development. By screening with fluorophore-assisted light inactivation in the developing mouse brain, we identified cartilage acidic protein-1B as a key molecule for lateral olfactory tract (LOT) formation and named it LOT usher substance (LOTUS). We further identified Nogo receptor-1 (NgR1) as a LOTUS-binding protein. NgR1 is a receptor of myelin-derived axon growth inhibitors, such as Nogo, which prevent neural regeneration in the adult. LOTUS suppressed Nogo-NgR1 binding and Nogo-induced growth cone collapse. A defasciculated LOT was present in lotus-deficient mice but not in mice lacking both lotus- and ngr1. These findings suggest that endogenous antagonism of NgR1 by LOTUS is crucial for normal LOT formation. |
