| First Author | Dolch A | Year | 2017 |
| Journal | Exp Dermatol | Volume | 26 |
| Issue | 5 | Pages | 449-451 |
| PubMed ID | 27714845 | Mgi Jnum | J:312262 |
| Mgi Id | MGI:6756918 | Doi | 10.1111/exd.13237 |
| Citation | Dolch A, et al. (2017) Contact allergens induce CD8(+) T cell-derived interleukin 10 that appears dispensable for regulation of contact hypersensitivity. Exp Dermatol 26(5):449-451 |
| abstractText | Interleukin 10 (IL-10) has been implied in the regulation of allergic contact dermatitis. Using transcriptional reporter mice we analyzed cellular sources of IL-10 during contact hypersensitivity (CHS) and identified IL-10 expressing CD8(+) T cells in the skin that are antigen-specific, display PD-1, an effector memory phenotype, and IL-10 expression comparable to that of CD4(+) T cells. However, in mice with a selective IL-10 deficiency in CD8(+) T cells CHS responses were comparable to that of controls, even in the absence of CD4(+) cells, suggesting that CD8(+) T cell-derived IL-10 does not contribute significantly to the resolution of CHS responses. |
