| Primary Identifier | MGI:3514313 | Allele Type | Transgenic |
| Attribute String | Inserted expressed sequence | Gene | Tg(KRT14-HPV16E7)2304Plam |
| Strain of Origin | FVB/NTac | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | This transgene contains a HPV16 fragment (nt79-883) encompassing both the E6 and E7 genes along with promoter, 3'UTR and polyA sequences from human KRT14. Only E7 is expressed due to the presence of a translation termination linker in the N terminal region of the E6 gene. Transgene expression is targeted toward epithelial tissues. Mice derived from founder 2304 had 2 copies of the transgene. Mice derived from founder 2332 had 7-8 copies of the transgene. this is a representative record for lines 2304 and 2332 which have identical phenotypes. |
