| First Author | Zhang X | Year | 2004 |
| Journal | Science | Volume | 305 |
| Issue | 5681 | Pages | 217 |
| PubMed ID | 15247473 | Mgi Jnum | J:94745 |
| Mgi Id | MGI:3513760 | Doi | 10.1126/science.1097540 |
| Citation | Zhang X, et al. (2004) Tryptophan hydroxylase-2 controls brain serotonin synthesis. Science 305(5681):217 |
| abstractText | Dysregulation of brain serotonin contributes to many psychiatric disorders. Tryptophan hydroxylase-2 (Tph2), rather than Tph1, is preferentially expressed in the brain. We report a functional (C1473G) single-nucleotide polymorphism in mouse Tph2 that results in the substitution of Pro447 with Arg447 and leads to decreased serotonin levels in PC12 cells. Moreover, in BALB/cJ and DBA/2 mice that are homozygous for the 1473G allele, brain serotonin tissue content and synthesis are reduced in comparison to C57Bl/6 and 129X1/SvJ mice that are homozygous for the 1473C allele. Our data provide direct evidence for a fundamental role of Tph2 in brain serotonin synthesis. |
