| First Author | Chen PY | Year | 2014 |
| Journal | Proc Natl Acad Sci U S A | Volume | 111 |
| Issue | 15 | Pages | 5514-9 |
| PubMed ID | 24706887 | Mgi Jnum | J:208873 |
| Mgi Id | MGI:5565135 | Doi | 10.1073/pnas.1404545111 |
| Citation | Chen PY, et al. (2014) The docking protein FRS2alpha is a critical regulator of VEGF receptors signaling. Proc Natl Acad Sci U S A 111(15):5514-9 |
| abstractText | Vascular endothelial growth factors (VEGFs) signal via their cognate receptor tyrosine kinases designated VEGFR1-3. We report that the docking protein fibroblast growth factor receptor substrate 2 (FRS2alpha) plays a critical role in cell signaling via these receptors. In vitro FRS2alpha regulates VEGF-A and VEGF-C-dependent activation of extracellular signal-regulated receptor kinase signaling and blood and lymphatic endothelial cells migration and proliferation. In vivo endothelial-specific deletion of FRS2alpha results in the profound impairment of postnatal vascular development and adult angiogenesis, lymphangiogenesis, and arteriogenesis. We conclude that FRS2alpha is a previously unidentified component of VEGF receptors signaling. |
