| First Author | Oka Y | Year | 2015 |
| Journal | Nature | Volume | 520 |
| Issue | 7547 | Pages | 349-52 |
| PubMed ID | 25624099 | Mgi Jnum | J:220379 |
| Mgi Id | MGI:5634596 | Doi | 10.1038/nature14108 |
| Citation | Oka Y, et al. (2015) Thirst driving and suppressing signals encoded by distinct neural populations in the brain. Nature 520(7547):349-52 |
| abstractText | Thirst is the basic instinct to drink water. Previously, it was shown that neurons in several circumventricular organs of the hypothalamus are activated by thirst-inducing conditions. Here we identify two distinct, genetically separable neural populations in the subfornical organ that trigger or suppress thirst. We show that optogenetic activation of subfornical organ excitatory neurons, marked by the expression of the transcription factor ETV-1, evokes intense drinking behaviour, and does so even in fully water-satiated animals. The light-induced response is highly specific for water, immediate and strictly locked to the laser stimulus. In contrast, activation of a second population of subfornical organ neurons, marked by expression of the vesicular GABA transporter VGAT, drastically suppresses drinking, even in water-craving thirsty animals. These results reveal an innate brain circuit that can turn an animal's water-drinking behaviour on and off, and probably functions as a centre for thirst control in the mammalian brain. |
