| First Author | Guo W | Year | 2013 |
| Journal | Neurosci Lett | Volume | 549 |
| Pages | 109-15 | PubMed ID | 23800542 |
| Mgi Jnum | J:201687 | Mgi Id | MGI:5515274 |
| Doi | 10.1016/j.neulet.2013.06.018 | Citation | Guo W, et al. (2013) Reduction of cerebral Abeta burden and improvement in cognitive function in Tg-APPswe/PSEN1dE9 mice following vaccination with a multivalent Abeta3-10 DNA vaccine. Neurosci Lett 549:109-15 |
| abstractText | To develop a safe and efficient Abeta vaccine for Alzheimer's disease, we constructed a plasmid DNA vaccine encoding ten repeats of Abeta3-10 and three copies of C3d-p28 as a molecular adjuvant and administered it intramuscularly in 12-month-old female Tg-APPswe/PSEN1dE9 mice. Therapeutic immunization with p(Abeta3-10)10-C3d-p28.3 stimulated a Th2 immune response that elicited therapeutic levels of anti-Abeta antibodies and improved cognitive function. In addition, the vaccine reduced the cerebral Abeta burden and astrocytosis without increasing the incidence of microhemorrhage. Our results indicate that the p(Abeta3-10)10-C3d-p28.3 vaccine is a promising immunotherapeutic option for Abeta vaccination in Alzheimer's disease. |
