| First Author | Li X | Year | 2016 |
| Journal | PLoS One | Volume | 11 |
| Issue | 3 | Pages | e0151147 |
| PubMed ID | 26954017 | Mgi Jnum | J:259802 |
| Mgi Id | MGI:6093201 | Doi | 10.1371/journal.pone.0151147 |
| Citation | Li X, et al. (2016) Traditional Chinese Nootropic Medicine Radix Polygalae and Its Active Constituent Onjisaponin B Reduce beta-Amyloid Production and Improve Cognitive Impairments. PLoS One 11(3):e0151147 |
| abstractText | Decline of cognitive function is the hallmark of Alzheimer's disease (AD), regardless of the pathological mechanism. Traditional Chinese medicine has been used to combat cognitive impairments and has been shown to improve learning and memory. Radix Polygalae (RAPO) is a typical and widely used herbal medicine. In this study, we aimed to follow the beta-amyloid (Abeta) reduction activity to identify active constituent(s) of RAPO. We found that Onjisaponin B of RAPO functioned as RAPO to suppress Abeta production without direct inhibition of beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) and gamma-secretase activities. Our mechanistic study showed that Onjisaponin B promoted the degradation of amyloid precursor protein (APP). Further, oral administration of Onjisaponin B ameliorated Abeta pathology and behavioral defects in APP/PS1 mice. Taken together, our results indicate that Onjisaponin B is effective against AD, providing a new therapeutic agent for further drug discovery. |
