| First Author | Tang Y | Year | 2018 |
| Journal | Exp Neurol | Volume | 305 |
| Pages | 89-96 | PubMed ID | 29641978 |
| Mgi Jnum | J:268595 | Mgi Id | MGI:6270909 |
| Doi | 10.1016/j.expneurol.2018.04.003 | Citation | Tang Y, et al. (2018) Estrogen-related receptor alpha is involved in Alzheimer's disease-like pathology. Exp Neurol 305:89-96 |
| abstractText | Estrogen-related receptor alpha (ERRalpha) is a transcriptional factor associated with mitochondrial biogenesis and energy metabolism. However, little is known about the role of ERRalpha in Alzheimer's disease (AD). Here, we report that in APP/PS1 mice, an animal model of AD, ERRalpha protein and mRNA were decreased in a region- and age-dependent manner. In HEK293 cells that stably express human full-length beta-amyloid precursor protein (APP), overexpression of ERRalpha inhibited the amyloidogenic processing of APP and consequently reduced Abeta1-40/1-42 level. ERRalpha overexpression also attenuated Tau phosphorylation at selective sites, with the concomitant reduction of glycogen synthase kinase 3beta (GSK3beta) activity. Interestingly, alterations of APP processing and Tau phosphorylation induced by hydrogen peroxide were reversed by ERRalpha overexpression in HEK/APP cells. These results indicated that ERRalpha plays a functional role in AD pathology. By attenuating both amyloidogenesis and Tau phosphorylation, ERRalpha may serve as a potential therapeutic target for AD. |
