| First Author | Pi G | Year | 2020 |
| Journal | Nat Commun | Volume | 11 |
| Issue | 1 | Pages | 183 |
| PubMed ID | 31924799 | Mgi Jnum | J:285645 |
| Mgi Id | MGI:6387663 | Doi | 10.1038/s41467-019-13919-3 |
| Citation | Pi G, et al. (2020) Posterior basolateral amygdala to ventral hippocampal CA1 drives approach behaviour to exert an anxiolytic effect. Nat Commun 11(1):183 |
| abstractText | The basolateral amygdala (BLA) and ventral hippocampal CA1 (vCA1) are cellularly and functionally diverse along their anterior-posterior and superficial-deep axes. Here, we find that anterior BLA (aBLA) and posterior BLA (pBLA) innervate deep-layer calbindin1-negative (Calb1-) and superficial-layer calbindin1-positive neurons (Calb1+) in vCA1, respectively. Photostimulation of pBLA-vCA1 inputs has an anxiolytic effect in mice, promoting approach behaviours during conflict exploratory tasks. By contrast, stimulating aBLA-vCA1 inputs induces anxiety-like behaviour resulting in fewer approaches. During conflict stages of the elevated plus maze task vCA1(Calb1+) neurons are preferentially activated at the open-to-closed arm transition, and photostimulation of vCA1(Calb1+) neurons at decision-making zones promotes approach with fewer retreats. In the APP/PS1 mouse model of Alzheimer's disease, which shows anxiety-like behaviour, photostimulating the pBLA-vCA1(Calb1+) circuit ameliorates the anxiety in a Calb1-dependent manner. These findings suggest the pBLA-vCA1(Calb1+) circuit from heterogeneous BLA-vCA1 connections drives approach behaviour to reduce anxiety-like behaviour. |
