| First Author | Chockanathan U | Year | 2020 |
| Journal | Sci Rep | Volume | 10 |
| Issue | 1 | Pages | 1077 |
| PubMed ID | 31974405 | Mgi Jnum | J:293058 |
| Mgi Id | MGI:6407288 | Doi | 10.1038/s41598-020-58038-y |
| Citation | Chockanathan U, et al. (2020) Altered dorsal CA1 neuronal population coding in the APP/PS1 mouse model of Alzheimer's disease. Sci Rep 10(1):1077 |
| abstractText | While the link between amyloid beta (Abeta) accumulation and synaptic degradation in Alzheimer's disease (AD) is known, the consequences of this pathology on population coding remain unknown. We found that the entropy, a measure of the diversity of network firing patterns, was lower in the dorsal CA1 region in the APP/PS1 mouse model of Abeta pathology, relative to controls, thereby reducing the population's coding capacity. Our results reveal a network level signature of the deficits Abeta accumulation causes to the computations performed by neural circuits. |
