| First Author | Meng Y | Year | 2017 |
| Journal | Brain Res | Volume | 1673 |
| Pages | 72-77 | PubMed ID | 28779977 |
| Mgi Jnum | J:268116 | Mgi Id | MGI:6270859 |
| Doi | 10.1016/j.brainres.2017.07.017 | Citation | Meng Y, et al. (2017) An Abeta3-10-KLH vaccine reduced Alzheimer's disease-like pathology and had a sustained effect in Tg-APPswe/PSEN1dE9 mice. Brain Res 1673:72-77 |
| abstractText | Alzheimer's disease is a neurodegenerative disease that affects many patients worldwide. The amyloid cascade hypothesis has been adopted by most researchers as the mechanism underlying Alzheimer's disease. Abeta plaques have been considered the core factor in the neurotoxic effect in Alzheimer's disease, though some controversy remains. Further effort is necessary to elucidate the mechanism and to develop effective treatments. Previous studies have indicated that eliminating Abeta plaques could improve synaptic plasticity and cognitive function. Researchers have developed various forms of vaccines to prevent Abeta deposition or eliminate Abeta plaques and have made some progress. We developed a new vaccine, Abeta3-10-KLH, to increase the level of the anti-Abeta immune response, and we show that this vaccine resulted in a sustained prevention of Abeta deposition at 4 months after cessation of the vaccine treatment. At the same time point, the expression of synaptophysin and NMDAR2B in APP/PS1 transgenic mice was increased by immunization. |
