| First Author | Sillerud LO | Year | 2013 |
| Journal | J Alzheimers Dis | Volume | 34 |
| Issue | 2 | Pages | 349-65 |
| PubMed ID | 23229079 | Mgi Jnum | J:350545 |
| Mgi Id | MGI:7663082 | Doi | 10.3233/JAD-121171 |
| Citation | Sillerud LO, et al. (2013) SPION-enhanced magnetic resonance imaging of Alzheimer's disease plaques in AbetaPP/PS-1 transgenic mouse brain. J Alzheimers Dis 34(2):349-65 |
| abstractText | In our program to develop non-invasive magnetic resonance imaging (MRI) methods for the diagnosis of Alzheimer's disease (AD), we have synthesized antibody-conjugated, superparamagnetic iron oxide nanoparticles (SPIONs) for use as an in vivo agent for MRI detection of amyloid-beta plaques in AD. Here we report studies in AbetaPP/PS1 transgenic mice, which demonstrate the ability of novel anti-AbetaPP conjugated SPIONs to penetrate the blood-brain barrier to act as a contrast agent for MR imaging of plaques. The conspicuity of the plaques increased from an average Z-score of 5.1 +/- 0.5 to 8.3 +/- 0.2 when the plaque contrast to noise ratio was compared in control AD mice with AD mice treated with SPIONs. The number of MRI-visible plaques per brain increased from 347 +/- 45 in the control AD mice, to 668 +/- 86 in the SPION treated mice. These results indicated that our SPION enhanced amyloid-beta detection method delivers an efficacious, non-invasive MRI detection method in transgenic mice. |
