| First Author | Wang L | Year | 2012 |
| Journal | Proc Natl Acad Sci U S A | Volume | 109 |
| Issue | 41 | Pages | 16743-8 |
| PubMed ID | 23019586 | Mgi Jnum | J:190314 |
| Mgi Id | MGI:5448588 | Doi | 10.1073/pnas.1208011109 |
| Citation | Wang L, et al. (2012) Epidermal growth factor receptor is a preferred target for treating amyloid-beta-induced memory loss. Proc Natl Acad Sci U S A 109(41):16743-8 |
| abstractText | Current understanding of amyloid-beta (Abeta) metabolism and toxicity provides an extensive list of potential targets for developing drugs for treating Alzheimer's disease. We took two independent approaches, including synaptic-plasticity-based analysis and behavioral screening of synthetic compounds, for identifying single compounds that are capable of rescuing the Abeta-induced memory loss in both transgenic fruit fly and transgenic mouse models. Two clinically available drugs and three synthetic compounds not only showed positive effects in behavioral tests but also antagonized the Abeta oligomers-induced activation of the epidermal growth factor receptor (EGFR). Such surprising converging outcomes from two parallel approaches lead us to conclude that EGFR is a preferred target for treating Abeta-induced memory loss. |
