| First Author | Lalonde R | Year | 2005 |
| Journal | Neurosci Lett | Volume | 390 |
| Issue | 2 | Pages | 87-92 |
| PubMed ID | 16169151 | Mgi Jnum | J:104569 |
| Mgi Id | MGI:3612319 | Doi | 10.1016/j.neulet.2005.08.028 |
| Citation | Lalonde R, et al. (2005) Exploratory activity and spatial learning in 12-month-old APP(695)SWE/co+PS1/DeltaE9 mice with amyloid plaques. Neurosci Lett 390(2):87-92 |
| abstractText | APP(695)SWE/co+PS1/DeltaE9 mice with Abeta plaques in neocortex and hippocampus were evaluated in tests of exploratory activity and spatial learning. On the initial testing day, 12-month-old APP(695)SWE/co+PS1/DeltaE9 mice spent more time than non-transgenic controls in the open arms of the elevated plus-maze. The bigenic group also travelled farther in the central region of the open-field without spending more time there. Only the bigenic group alternated above chance in the T-maze. In the Morris water maze, APP(695)SWE/co+PS1/DeltaE9 mice were impaired during acquisition of the hidden platform sub-task and the probe trial but not in the visible platform test. These results indicate a selective spatial deficit and disinhibitory tendencies in a mouse model with amyloid pathology. |
