| First Author | Guillot-Sestier MV | Year | 2021 |
| Journal | Commun Biol | Volume | 4 |
| Issue | 1 | Pages | 711 |
| PubMed ID | 34112929 | Mgi Jnum | J:308484 |
| Mgi Id | MGI:6728186 | Doi | 10.1038/s42003-021-02259-y |
| Citation | Guillot-Sestier MV, et al. (2021) Microglial metabolism is a pivotal factor in sexual dimorphism in Alzheimer's disease. Commun Biol 4(1):711 |
| abstractText | Age and sex are major risk factors in Alzheimer's disease (AD) with a higher incidence of the disease in females. Neuroinflammation, which is a hallmark of AD, contributes to disease pathogenesis and is inexorably linked with inappropriate microglial activation and neurodegeneration. We investigated sex-related differences in microglia in APP/PS1 mice and in post-mortem tissue from AD patients. Changes in genes that are indicative of microglial activation were preferentially increased in cells from female APP/PS1 mice and cells from males and females were morphological, metabolically and functionally distinct. Microglia from female APP/PS1 mice were glycolytic and less phagocytic and associated with increased amyloidosis whereas microglia from males were amoeboid and this was also the case in post-mortem tissue from male AD patients, where plaque load was reduced. We propose that the sex-related differences in microglia are likely to explain, at least in part, the sexual dimorphism in AD. |
