| First Author | Kuhla A | Year | 2017 |
| Journal | Neuroimage Clin | Volume | 15 |
| Pages | 581-586 | PubMed ID | 28652970 |
| Mgi Jnum | J:264960 | Mgi Id | MGI:6198979 |
| Doi | 10.1016/j.nicl.2017.06.009 | Citation | Kuhla A, et al. (2017) APPswe/PS1dE9 mice with cortical amyloid pathology show a reduced NAA/Cr ratio without apparent brain atrophy: A MRS and MRI study. Neuroimage Clin 15:581-586 |
| abstractText | Transgenic animal models of Abeta pathology provide mechanistic insight into some aspects of Alzheimer disease (AD) pathology related to Abeta accumulation. Quantitative neuroimaging is a possible aid to improve translation of mechanistic findings in transgenic models to human end phenotypes of brain morphology or function. Therefore, we combined MRI-based morphometry, MRS-based NAA-assessment and quantitative histology of neurons and amyloid plaque load in the APPswe/PS1dE9 mouse model to determine the interrelationship between morphological changes, changes in neuron numbers and amyloid plaque load with reductions of NAA levels as marker of neuronal functional viability. The APPswe/PS1dE9 mouse showed an increase of Abeta plaques, loss of neurons and an impairment of NAA/Cr ratio, which however was not accompanied with brain atrophy. As brain atrophy is one main characteristic in human AD, conclusions from murine to human AD pathology should be drawn with caution. |
