| First Author | Lalonde R | Year | 2004 |
| Journal | Neurosci Lett | Volume | 369 |
| Issue | 2 | Pages | 156-61 |
| PubMed ID | 15450687 | Mgi Jnum | J:93096 |
| Mgi Id | MGI:3055711 | Doi | 10.1016/j.neulet.2004.07.069 |
| Citation | Lalonde R, et al. (2004) Exploratory activity, anxiety, and motor coordination in bigenic APPswe + PS1/DeltaE9 mice. Neurosci Lett 369(2):156-61 |
| abstractText | Bigenic APPswe + PS1/DeltaE9 mice with Abeta plaque formation in neocortex and hippocampus were evaluated in three tests measuring exploratory activity. By comparison to a non-transgenic group controlled for age and gender, 7-month-old APPswe + PS1/DeltaE9 mice spent more time in the open arms and had higher open/total entries and duration in the elevated plus-maze, indicative of disinhibitory tendencies. On the contrary, the groups did not differ in T-maze and open-field tests. Moreover, the motor coordination of the bigenic group was equivalent to that of controls in stationary beam, coat-hanger, rotorod, and grip strength tests. No mouse displayed neurological signs, such as pathological reflexes, myoclonus, or convulsions. The results in the elevated plus-maze test are akin to the loss of inhibitory control observed in some patients with Alzheimer's disease. |
